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KMID : 0390020110210030197
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Pediatric Allergy and Respiratory Disease
2011 Volume.21 No. 3 p.197 ~ p.206
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Prevalence of Allergic Diseases in Children according to Mode of Delivery
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Lee Yong-Ju
Jee Hye-Mi
Kim Byoung-Ju
Kim Hyo-Bin
Yu Jin-Ho
Lee So-Yeon
Kim Woo-Kyung
Sohn Myung-Hyun
Kim Kyu-Earn
Hong Se-hoon
Kim Kyung-Won
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Abstract
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Purpose:It has been suggested that caesarean section is a risk factor for allergic diseases under the ‘hygiene hypothesis’, but it remains controversial. In this study, we examined the association between mode of delivery and development of allergic diseases.
Methods:The Korean International Study of Asthma and Allergies in Childhood questionnaire was used to survey 8,404 elementary and middle-school students in Seoul between April and October 2008. We categorized children into a caesarean section group and a vaginal delivery group, and surveyed the prevalence of asthma, allergic rhinitis, and atopic dermatitis
Results:No differences in the prevalence of “wheeze ever” (P =0.418), “wheezing the last 12 months” (P =0.152), and “diagnosis of asthma ever” (P =0.382) were observed between the caesarean section group and the vaginal delivery group. The prevalence of “rhinitis ever” (P =0.609), “rhinitis the last 12 months” (P =0.788), and “diagnosis of allergic rhinitis ever” (P =0.700) was also similar between the two groups. The prevalence of “itchy eczema ever” (P =0.065), “itchy
eczema last 12 months” (P =0.381), and a “diagnosis of atopic dermatitis ever” (P =0.162) also did not show any differences between the two groups. However, in subjects with a family history of allergic disease, the caesarean section group had the higher prevalence of “diagnosis of asthma ever” (11.3% vs. 9.2%, P =0.032) than that in the vaginal delivery group.
Conclusion:We found an association between mode of delivery and the subsequent development of asthma in children with a family history of allergic disease in Seoul, Korea.
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KEYWORD
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Caesarean section, Mode of delivery, Children, Asthma, Allergic rhinitis, Atopic dermatitis
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